The most important change would occur in the Middle East, where "decades of putting Israel's interests first" would end.
Jackson believes that, although "Zionists who have controlled American policy for decades" remain strong, they'll lose a great deal of their clout when Barack Obama enters the White House.
"Obama is about change," Jackson told me in a wide-ranging conversation. "And the change that Obama promises is not limited to what we do in America itself. It is a change of the way America looks at the world and its place in it."
It's a wide-ranging interview that touches on a number of subjects, from the Bradley effect (whether people may be telling pollsters they favor the black candidate, but won't end up voting for him.) to economics and more foreign affairs:
On Iran, he strongly supports Obama's idea of opening a direct dialogue with the leadership in Tehran. "We've got to talk to tell them what we want and hear what they want," Jackson says. "Nothing is gained by not talking to others."
Would that mean ignoring the four UN Security Council resolutions that demand an end to Iran's uranium-enrichment program? Jackson says direct talks wouldn't start without preparations.
"Barack wants an aggressive and dynamic diplomacy," he says. "He also wants adequate preparatory work. We must enter the talks after the ground has been prepared," he says.
Jackson is especially critical of President Bush's approach to the Israel-Palestine conflict.
"Bush was so afraid of a snafu and of upsetting Israel that he gave the whole thing a miss," Jackson says. "Barack will change that," because, as long as the Palestinians haven't seen justice, the Middle East will "remain a source of danger to us all."
"Barack is determined to repair our relations with the world of Islam and Muslims," Jackson says. "Thanks to his background and ecumenical approach, he knows how Muslims feel while remaining committed to his own faith."